中国 EN 400-660-9091

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

CIB1 polyclonal antibody

货号: BS60061
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS60061
Product Name :CIB1 polyclonal antibody
Swiss-Prot :Q99828
Host :Rabbit
Reactivity :Human,Rat
Applications :WB
Application_all :WB: 1:500~1:1000
Background :Platelets regulate the function of Integrin α2b/β3 (GPIIb/IIIa), the platelet Fibrinogen receptor, which is involved in the binding of proteins to integrin cytoplasmic domains. A novel protein, CIB, for calcium- and integrin-binding protein (also designated as Kip for kinase interacting protein, SIP2-28 and DNA-PKcs interacting protein), binds specifically at the cytoplasmic domain of α2b by a number of positively charged residues in its binding site. Binding of CIB to the α2b is affected by fluctuations in the intracellular calcium concentration. In aggregated platelets, endogenous CIB and α2b/β3 translocate to the Triton X-100-insoluble cytoskeleton, demonstrating that the cellular localization of CIB is regulated. CIB also binds to DNA-PKcs, which is a nu-clear protein serine/threonine kinase that plays a role in the DNA repair and recombination process of lymphoid development. Fnk also binds to the CIB, suggesting that CIB may be a regulatory subunit of polo-like kinases. CIB shows significant homology to calcineurin B and calmodulin, and its mRNA levels are ubiquitously expressed in various human tissues.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :CIB1 polyclonal antibody detects endogenous levels of CIB1 protein.
BiowMW :~ 22 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Calcium and integrin-binding protein 1; Calcium- and integrin-binding protein; CIBP; Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; KIP; SNK-interacting protein 2-28; SIP2-28; CIB1; CIB; KIP; PRKDCIP
Immunogen :A synthetic peptide corresponding to residues in Human CIB1.
Conjugate :Unconjugated
Modification :Unmodification
Western blot (WB) analysis of CIB1 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:H9C2 whole cell lysate Lane3:Rat brain tissue lysate

关注我们

400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com