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EWSR1 polyclonal antibody

货号: BS5715

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5715

Product Name :EWSR1 polyclonal antibody

Swiss-Prot :Q01844

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :EWS is a nuclear RNA-binding protein. As a result of chromosome translocation, the EWS gene is fused to a variety of transcription factors, including ATF-1 in human neoplasias. In the Ewing family of tumors, the N-terminal domain of EWS is fused to the DNA-binding domain of various ETS transcription factors, including Fli-1, Erg, ETV1, E1AF and FEV. The EWS/Fli-1 chimeric protein acts as a more potent transcriptional activator than Fli-1 and can promote cell transformation. Two functional regions have been identified in EWS; an amino-terminal region (domain A), that has little transactivation activity but transforms efficiently when fused to Fli-1, and a distal region (domain B), which shows transactivation activity but transforms less efficiently when fused to Fli-1.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :EWSR1 polyclonal antibody detects endogenous levels of EWSR1 protein.

BiowMW :~ 95 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :RNA-binding protein EWS; EWS oncogene; Ewing sarcoma breakpoint region 1 protein; EWS

Immunogen :Synthetic peptide, corresponding to the 465-510 of Human EWSR1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of EWSR1 pAb at 1:2000 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:PC3 whole cell lysate(40ug)

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）