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ELMO1 polyclonal antibody

货号: BS5711
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS5711
Product Name :ELMO1 polyclonal antibody
Swiss-Prot :Q92556
Host :Rabbit
Reactivity :Human,Mouse,Rat
Applications :WB
Application_all :WB: 1:500~1:1000
Background :Elmo (engulfment and cell motility) proteins share similarity to C. elegans CED-12. The C. elegans genes ced-2, ced-5, ced-10 and ced-12, and their mammalian homologs, CRKII, DOCK1, RAC1 and ELMO, mediate cytoskeletal rear-rangements during phagocytosis of apoptotic cells as well as cell motility. Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase-mediated tyrosine phosphorylation of Elmo1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The Rho G-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK 180 and Crk II and may be required in complex with DOCK 180 to activate Rac/Rho small GTPases.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :ELMO1 polyclonal antibody detects endogenous levels of ELMO1 protein.
BiowMW :~ 84 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Engulfment and cell motility protein 1; Protein ced-12 homolog; ELMO; KIAA0281
Immunogen :Synthetic peptide, corresponding to the 81-126 of Human ELMO1.
Conjugate :Unconjugated
Modification :Unmodification
Western blot (WB) analysis of ELMO1 polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:sp2/0 cell lysate Lane3:Rat brain tissue lysate

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com