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EEA1 polyclonal antibody

货号: BS5707

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS5707

Product Name :EEA1 polyclonal antibody

Swiss-Prot :Q15075

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Early endosomes are cytoplasmic compartments that function in receiving and sorting endocytosed proteins for vesicular transport. EEA1 (early endosome antigen 1) is a peripheral membrane protein that co-localizes with the transferrin receptor and Rab5 on early endosomes. EEA1 contains a calmodulin-binding IQ motif and cysteine rich finger motif necessary for its specific localization to the early endosomes. EEA1 has sequence homology to several yeast proteins that have been implicated in membrane trafficking, including Vps27, Fab1 and Vac1. Evidence suggests a possible role for EEA1 in mediating the regulatory effects of 3'-phosphoinositides on membrane trafficking.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :EEA1 polyclonal antibody detects endogenous levels of EEA1 protein.

BiowMW :~ 162 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Early endosome antigen 1; Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2; ZFYVE2

Immunogen :Synthetic peptide, corresponding to amino acids 264-309 of Human EEA1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of EEA1 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate

APP mediates tau uptake and its overexpression leads to the exacerbated tau pathology

JournalCELLULAR AND MOLECULAR LIFE SCIENCES

ApplicationIF

IF9.207

SpeciesHuman

PMID37071198