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Dishevelled 3 polyclonal antibody

货号: BS5705

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS5705

Product Name :Dishevelled 3 polyclonal antibody

Swiss-Prot :Q92997

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Dishevelled 3 polyclonal antibody detects endogenous levels of Dishevelled 3 protein.

BiowMW :~ 90 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Wntβ catenin signaling，Regulation of Microtubule Dynamics,

Alternative Name :Segment polarity protein dishevelled homolog DVL-3; Dishevelled-3; Dishevelled3; DSH homolog 3; DVL3; KIAA0208

Immunogen :Synthetic peptide, corresponding to amino acids 368-413 of Human Dishevelled 3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Dishevelled 3 polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Lane2:Raw264.7 cell lysate Lane3:Rat kidney tissue lysate