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COMT polyclonal antibody

货号: BS5671

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5671

Product Name :COMT polyclonal antibody

Swiss-Prot :P21964

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Catechol-O-methyltransferase (COMT) plays a crucial role in the regulation of central dopaminergic systems by catalyzing the inactivation of catechol-amines. It is widely distributed in most tissues in soluble and membrane-bound forms. COMT-mediated methylation metabolism of catecholamine neurotransmitters is a first-line detoxification pathway. A Val158Met polymorphism of the COMT gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex of the brain. Sequential conversion of estradiol to methoxyestradiol by COMT, contributes to the antimitogenic effects of estradiol on vascular smooth muscle cell growth via estrogen receptor-independent mechanisms. COMTD1 (catechol O-methyltransferase domain-containing protein 1) is a 262 amino acid single-pass type II membrane protein that belongs to the methyltransferase superfamily.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :COMT polyclonal antibody detects endogenous levels of COMT protein.

BiowMW :~ 30 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Catechol O-methyltransferase

Immunogen :Synthetic peptide, corresponding to amino acids 111-156 of Human COMT.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of IL3RA pAb at 1:500 dilution Lane1:Myla2059 whole cell lysate(20ug) Lane2:U-87MG whole cell lysate(40ug) Lane3:HepG2 whole cell lysate(40ug) Lane4:HUT78 whole cell lysate(40ug) Lane5:L02 whole cell lysate(40ug)