Product Name :Cyclin E2 (N387) polyclonal antibody
Application_all :IHC: 1:50~1:200
IF: 1:50~1:200
Background :Cyclin E, along with the three cyclin D proteins and cyclin C, has been shown to represent a putative G1 cyclin on the basis of its cyclic pattern of mRNA expression, with maximal levels being detected near the G1/S boundary. cyclin E has been found to be associated with the transcription factor E2F in a temporally regulated manner. Cyclin E2 is a cyclin E-related protein that specifically interacts with Cdk2 and Cdk3 and with p27 and p21. Cyclin E2 expression peaks at the G1/S phase transition of the cell cycle, in parallel with cyclin E. Whereas cyclin E1 is expressed in most proliferating normal and tumor cells, cyclin E2 levels are low or undetectable in nontransformed cells, and are elevated in tumor-derived cells.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Cyclin E2 (N387) polyclonal antibody detects endogenous levels of Cyclin E2 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :G1/S-specific cyclin-E2; CCNE2
Immunogen :Synthetic peptide, corresponding to amino acids 361-410 of Human Cyclin E2.
Modification :Unmodification
