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AChE (K585) polyclonal antibody

货号: BS3694

价格：￥ 660

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS3694

Product Name :AChE (K585) polyclonal antibody

Swiss-Prot :P22303

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC

Application_all :IHC:1:50~1:200

Background :Acetylcholinesterase (AChE) hydrolyzes acetylcholine at synaptic junctions.Alternative mRNA splicing gives rise to three forms of AChE. The T form, also known as the asymmetric form, is soluble and is present in synapses. The H form is also known as the globular form and is present on the outer surfaces of cell membranes. The R form is not known to be a functional species. AChE globular form subunits are GPI-anchored to cell membranes and asymmetric subunits are anchored to basal lamina components by a collagen tail. The catalytic subunits of AChE are oligomers composed of disulfide-linked homodimers. The loss of AChE from cholinergic and noncholinergic neurons in the brain is seen in patients with Alzheimer’s disease. However, AChE activity is increased around amyloid plaques, which may be due to a disturbance in calcium homeostasis involving the opening of L-type voltage-dependent calcium channels.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AChE (K585) polyclonal antibody detects endogenous levels of AChE protein.

BiowMW :~ 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Acetylcholinesterase; AChE; ACHE; ACES

Immunogen :Synthetic peptide, corresponding to amino acids 560-600 of Human AChE.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry (IHC) analyzes of AChE (K585) pAb bin paraffin-embedded human lung carcinoma tissue at 1:50,showing membrnae and nuclear staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.