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CNPase (A108) polyclonal antibody（KU）

货号: BS3461

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS3461

Product Name :CNPase (A108) polyclonal antibody（KU）

Swiss-Prot :P09543

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :CNPase (2',3'-Cyclic Nucleotide 3'-Phosphodiesterase) exists in two forms: 46kDa (CNP1) and 48kDa (CNP2). It is expressed at high levels by oligodendrocytes in the central nervous system and by Schwann cells in the peripheral nervous system and is virtual absent in other cell types. CNPase activity is decreased in demyelinating diseases such as multiple sclerosis. CNPase gene is localized to chromosome 17q21, very near the BRCA 1 familial breast cancer gene.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CNPase (A108) polyclonal antibody detects endogenous levels of CNPase protein.

BiowMW :~ 47 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Neuronal and Glial Cell Marker Atlas,

Alternative Name :2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNP

Immunogen :Synthetic peptide, corresponding to amino acids 61-110 of Human CNPase.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CNP pAb at 1:1000 dilution Lane1:The Brain tissue lysate of Mouse(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:CT-26 whole cell lysate(40ug) Lane4:SGC7901 whole cell lysate(40ug) Lane5:K562 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of CNPase (A108) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

Comparative Proteomic Analysis of Differentially Expressed Proteins between Peripheral Sensory and Motor Nerves

JournalJournal Of Proteome Research

ApplicationWB,IHC

IF4.074

SpeciesRat

PMID22554246
BMP2, BMP4, noggin, BMPRIA, BMPRIB, and BMPRII are differentially expressed in the adult rat spinal cord

JournalNeuroscience

ApplicationIF,IHC

IF3.59

SpeciesRat

PMID
Local Injection of Lentivirus Encoding LINGO-1-shRNA Promotes Functional Recovery in Rats With Complete Spinal Cord Transection

JournalSpine

ApplicationIF

IF3.468

SpeciesRat

PMID23759802
Tissue engineering with peripheral blood-derived mesenchymal stem cells promotes the regeneration of injured peripheral nerves

JournalExperimental Neurology

ApplicationICC

IF4.562

SpeciesRat

PMID28283336
Alterations of myelin morphology and oligodendrocyte development in early stage of Alzheimer’s disease mouse model

JournalNeuroscience Letters

ApplicationWB

IF3.046

SpeciesMouse

PMID28174059