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FoxC1/2 (K138) polyclonal antibody（KU）

货号: BS2300

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS2300

Product Name :FoxC1/2 (K138) polyclonal antibody（KU）

Swiss-Prot :Q12948/Q99958

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The forkhead transcription factor genes FOXC1 (Mf1) and FOXC2 (Mfh1) interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop. The genes have similar, dose-dependent functions, and compensate for each other in the early development of the heart, blood vessels and somites. Both FOXC1 and FOXC2 are expressed in the mesenchyme from which the ocular drainage structures derive. FOXC1 and FOXC2 also interact in kidney and heart development. Mutations in the FOXC1 gene result in Axenfeld-Rieger malformations of the anterior segment of the eye and lead to an increased susceptibility of glaucoma, including juvenile glaucoma. Functional regions in FOXC1 are required for nuclear localization and transcriptional regulation. Specifically, two regions in the FOXC1 forkhead domain, one rich in basic amino acid residues, and a second, highly conserved among all FOX proteins, are necessary for nuclear localization of the FOXC1 protein.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FoxC1/2 (K138) polyclonal antibody detects endogenous levels of FoxC1 and FoxC2 protein.

BiowMW :~ 57 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3; FOXC1; FKHL7; FREAC3; Forkhead box protein C2; Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; MFH-1 protein; Transcription factor FKH-14; FOXC2; FKHL14; MFH1

Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human FoxC1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FoxC1/2 (K138) pAb at 1:500 dilution Lane1:3T3-L1 whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:Hela whole cell lysate(40ug) Lane5:HEK293T whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of FoxC1/2 (K138) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

Foxc2 enhances proliferation and inhibits apoptosis through activating Akt/mTORC1 signaling pathway in mouse preadipocytes

JournalJournal Of Lipid Research

ApplicationWB

IF4.483

SpeciesMouse

PMID26113535