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CtBP2 (P432) polyclonal antibody（KU）

货号: BS2287

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS2287

Product Name :CtBP2 (P432) polyclonal antibody（KU）

Swiss-Prot :P56545

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :CtBP1 and the related protein CtBP2 are characterized as C-terminal binding proteins of adenovirus E1A, and they preferentially associate with the E1A via a 5 amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation.CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of deltaEF1, a cellular zinc finger-homeodomainprotein, and thereby enhances deltaEF1-induced transcriptional silencing. In addition, CtBP complexes with CtIP, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CtBP2 (P432) polyclonal antibody detects endogenous levels of CtBP2 protein.

BiowMW :~48.0 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C-terminal-binding protein 2; CtBP2; CTBP2

Immunogen :Synthetic peptide, corresponding to amino acids 400-450 of Human CtBP2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CtBP2 (P432) polyclonal antibody at 1:500 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:H1792 whole cell lysate(40ug) Lane3:Panc1 whole cell lysate(40ug) Lane4:H9C2 whole cell lysate(40ug) Lane5:AML-12 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of CtBP2 (P432) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Disruption of Glutamate Release and Uptake-Related Protein Expression After Noise-Induced Synaptopathy in the Cochlea

JournalFrontiers in Cell and Developmental Biology

ApplicationIF

IF6.684

SpeciesMouse

PMID34422838
Defects in hair cells disrupt the development of auditory peripheral circuitry

Journal10.1038/s41467-024-55275-x

ApplicationIHC

IF14.7

SpeciesMouse

PMID39738090