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ADCY 5/6 (F1052) polyclonal antibody

货号: BS2208

价格：￥ 660

货期：现货（1-2个工作日）

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No. :BS2208

Product Name :ADCY 5/6 (F1052) polyclonal antibody

Swiss-Prot :O95622/O43306

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :A cyclase V, also known as ADCY5, is a 1,261 amino acid Adenylyl cyclase that localizes to cellular membranes and contains two guanylate cyclase domains. Similar to other A cyclase proteins, A cyclase V uses magnesium as a cofactor to catalyze the conversion of ATP to cAMP. A cyclase VI, also known as ADCY6 (adenylate cyclase type 6), is a 1,168 amino acid A cyclase that localizes to the membrane and contains two guanylate cyclase domains. Using magnesium as a cofactor, A cyclase VI functions as a calcium-inhibitable A cyclase that catalyzes the conversion of ATP to 3',5'-cyclic AMP and diphosphate and plays a role in a variety of events throughout the body. Multiple isoforms of A cyclase VI exist due to alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ADCY 5/6 (F1052) polyclonal antibody detects endogenous levels of Adenylate cyclase type 5 and Adenylate cyclase type 6 protein.

BiowMW :~ 130, 139 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :A cyclase V; A cyclase VI; Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; ADCY5; Adenylate cyclase type 6; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase; ADCY6; KIAA0422

Immunogen :Synthetic peptide, corresponding to amino acids 1111-1160 of Human ADCY 5

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ADCY 5/6 (F1052) polyclonal antibody at 1:500 dilution Lane1:Panc1 whole cell lysate(40ug) Lane2:PC3 whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:Hela whole cell lysate(40ug) Lane5:MCF-7 whole cell lysate(40ug) Lane6:The Pancreas tissue lysate of Mouse(40ug) Lane7:The Pancreas tissue lysate of Rat(40ug)

Immunohistochemistry (IHC) analyzes of ADCY 5/6 (F1052) pAb in paraffin-embedded human breast carcinoma tissue at 1:50,showing cytoplasm and membrane staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Immunohistochemistry (IHC) analyzes of ADCY 5/6 (F1052) pAb in paraffin-embedded human stomach carcinoma tissue at 1:50,showing cytoplasm and membrane staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.