中国 EN 400-660-9091

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

ACCα (K86) polyclonal antibody(KU)

货号: BS1377
价格 660
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS1377
Product Name :ACCα (K86) polyclonal antibody(KU)
Swiss-Prot :Q13085
Host :Rabbit
Reactivity :Human,Mouse,Rat,Pig
Applications :WB IHC
Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200
Background :Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl- CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted Serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the short-term regulatory mechanism of the enzyme. The gene encoding ACCα, which maps to human chromosome 17, encodes the 265 kDa α form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of ACCα except for an additional peptide of about 150 amino acids at the N-terminus.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :ACCα (H74) polyclonal antibody detects endogenous levels of ACCα protein.
BiowMW :~ 265 kDa
Note :For research use only, not for use in diagnostic procedure.
Pathway :Warburg Effect,AMPK Signaling Pathway,
Alternative Name :Acetyl-CoA carboxylase 1; Short name=ACC1; ACC-alpha; Biotin carboxylase; ACACA; ACAC; ACC1; ACCA
Immunogen :Synthetic peptide, corresponding to amino acids 50-100 of Human ACCα.
Conjugate :Unconjugated
Modification :Unmodification
Western blot (WB) analysis of ACCα (K86) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:Jurkat cell lysate Lane3:NIH-3T3 cell lysate Lane4:PC12 cell lysate
Immunohistochemistry (IHC) analyzes of ACCα (K86) pAb in paraffin-embeddedhuman stomach carcinoma tissue at 1:50.showing cell membrane, cytoplasmicstaining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.
  • Mark4 promotes adipogenesis and triggers apoptosis in 3T3-L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways
    JournalBiology Of The Cell
    ApplicationWB
    IF4.458
    SpeciesMouse
    PMID
  • Impact of high altitude on the hepatic fatty acid oxidation and synthesis in rats
    JournalBiochemical And Biophysical Research Communications
    ApplicationWB
    IF2.705
    SpeciesRat
  • Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway
    JournalCell Death & Disease
    ApplicationWB,IF
    IF8.469
    SpeciesMouse
  • Inhibition of Mitochondrial Fission and NOX2 Expression Prevent NLRP3 Inflammasome Activation in the Endothelium: The Role of Corosolic Acid Action in the Amelioration of Endothelial Dysfunction
    JournalAntioxidants & Redox Signaling
    ApplicationWB
    IF5.828
    SpeciesRat
  • Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner
    JournalPharmacological Research
    ApplicationWB
    IF5.574
    SpeciesRat

关注我们

400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com