Product Name :FGFR1 OP (N371) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
IF: 1:50~1:200
Background :FOP, also known as FGFR1OP (FGFR1 oncogene partner), is a 399 amino acid protein that localizes to the centrosome and contains one LisH domain. Expressed ubiquitously with highest expression in kidney, heart, muscle, colon, liver, testis and pancreas, FOP functions as a homodimer that interacts with EB1 and CEP350 and is essential for anchoring microtubules to centrosomes. Chromosomal aberrations that involve the FOP gene are associated with the pathogenesis of stem cell myeloproliferative disorder (MPD), a condition that is characterized by eosinophilia and myeloid hyperplasia and ultimately leads to acute myeloid leukemia. FOP is expressed as multiple isoforms that are produced by alternative splicing events.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term.
Avoid freeze-thaw cycles.
Specificity :FGFR1OP (N371) polyclonal antibody detects endogenous levels of
FGFR1OP protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :FGFR1 oncogene partner;
FGFR1OP;
Fibroblast growth factor receptor 1 oncogene partner; FOP
Immunogen :Synthetic peptide, corresponding to amino acids 341-390 of Human FGFR1 OP.
Modification :Unmodification
