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FasL (P137) polyclonal antibody(KU)

货号: BS1122
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS1122
Product Name :FasL (P137) polyclonal antibody(KU)
Swiss-Prot :P48023
Host :Rabbit
Reactivity :Human,Mouse,Rat
Applications :WB IHC IF
Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Background :Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the Perforin-based process. Independently, a FASbased mechanism involves the transducing molecule FAS (also designated Apo-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :FAS ligand/TNFL6 (P137) polyclonal antibody detects endogenous levels of FAS ligand/TNFL6 protein.
BiowMW :~ 31 kDa
Note :For research use only, not for use in diagnostic procedure.
Pathway :Death Receptor Signaling,
Alternative Name :Tumor necrosis factor ligand superfamily member 6; Apoptosis antigen ligand; APTL; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; CD178; Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form; Receptor-binding FasL ectodomain; Soluble Fas ligand; sFasL; ADAM10-processed FasL form; APL; FasL intracellular domain; FasL ICD; SPPL2A-processed FasL form; SPA; FASLG; APT1LG1; CD95L; FASL; TNFSF6
Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human FasL.
Conjugate :Unconjugated
Modification :Unmodification
Western blot (WB) analysis of FASL (P137) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:PC12 whole cell lysate
Immunohistochemistry (IHC) analyzes of FasL (P137) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
  • Targeted mutation of Fas ligand gene attenuates brain inflammation in experimental stroke
    JournalBrain Behavior And Immunity
    ApplicationWB
    IF6.633
    SpeciesMouse
    PMID
  • Methylated actinomycin D, a novel actinomycin D analog induces apoptosis in HepG2 cells through Fas- and mitochondria-mediated pathways
    JournalMolecular Carcinogenesis
    ApplicationWB
    IF4.784
    SpeciesHuman
  • Neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: A possible molecular mechanism
    JournalEuropean Journal Of Pharmacology
    ApplicationWB
    IF4.432
    SpeciesRat
    PMID
  • NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G2/M cell cycle arrest
    JournalFood And Chemical Toxicology
    ApplicationWB
    IF3.775
    SpeciesHuman
    PMID
  • Mono(2‐ethylhexyl) phthalate induces apoptosis in p53‐silenced L02 cells via activation of both mitochondrial and death receptor pathways
    JournalEnvironmental Toxicology
    ApplicationWB
    IF3.118
    SpeciesHuman
    PMID

关注我们

400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com