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FasL (P137) polyclonal antibody（KU）

货号: BS1122

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1122

Product Name :FasL (P137) polyclonal antibody（KU）

Swiss-Prot :P48023

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the Perforin-based process. Independently, a FASbased mechanism involves the transducing molecule FAS (also designated Apo-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FAS ligand/TNFL6 (P137) polyclonal antibody detects endogenous levels of FAS ligand/TNFL6 protein.

BiowMW :~ 31 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Death Receptor Signaling,

Alternative Name :Tumor necrosis factor ligand superfamily member 6; Apoptosis antigen ligand; APTL; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; CD178; Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form; Receptor-binding FasL ectodomain; Soluble Fas ligand; sFasL; ADAM10-processed FasL form; APL; FasL intracellular domain; FasL ICD; SPPL2A-processed FasL form; SPA; FASLG; APT1LG1; CD95L; FASL; TNFSF6

Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human FasL.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of FASL (P137) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:PC12 whole cell lysate

Immunohistochemistry (IHC) analyzes of FasL (P137) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Protective Efficacy of Vitamins C and E on p,p′-DDT-Induced Cytotoxicity via the ROS-Mediated Mitochondrial Pathway and NF-κB/FasL Pathway

JournalPLoS One

ApplicationWB

IF2.776

SpeciesHuman

PMID25464339
Isoflurane Damages the Developing Brain of Mice and Induces Subsequent Learning and Memory Deficits through FASL-FAS Signaling

JournalBiomed Research International

ApplicationWB

IF2.276

SpeciesMouse

PMID26609525
Saponin 6 derived from Anemone taipaiensis induces U87 human malignant glioblastoma cell apoptosis via regulation of Fas and Bcl‑2 family proteins

JournalMolecular Medicine Reports

ApplicationWB

IF2.1

SpeciesHuman

PMID27175997
Soluble epoxide hydrolase (Ephx2) silencing attenuates the hydrogen peroxide-induced oxidative damage in IEC-6 cells

JournalArchives of Medical Science

ApplicationWB

IF3.318

SpeciesRat

PMID34336035
Over-Expression of ATPase II Alleviates Ethanol-Induced Hepatocyte Injury in HL-7702 Cells

JournalMedical Science Monitor

ApplicationWB

IF1.918

SpeciesHuman

PMID30457983