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DNA pol β (Q324) polyclonal antibody（KU）

货号: BS1091

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1091

Product Name :DNA pol β (Q324) polyclonal antibody（KU）

Swiss-Prot :P06746

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol α, β, δ and ε are involved in DNA replication and repair. DNA pol δ and DNA pol ε are multisubunit enzymes, with DNA pol δ consisting of two subunits—p125, which interacts with the sliding DNA clamp protein PCNA, and p50. The nuclear-encoded DNA pol γ is the only DNA polymerase required for the replication of the mitochondrial DNA. DNA pol ζ is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis. DNA pol θ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :DDNA pol β (Q324) polyclonal antibody detects endogenous levels of DNA pol β protein.

BiowMW :~ 38 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DNA directed DNA polymerase beta; DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DPOLB; MGC125976; Pol B; Pol beta; PolB; Polymerase (DNA directed) beta;

Immunogen :Synthetic peptide, corresponding to amino acids 301-350 of Human DNA pol β.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of DNA pol β (Q324) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:Rat brain tissue lysate

Immunohistochemistry (IHC) analyzes of DNA Polymerase DNA pol β (Q324) pAb in paraffin-embedded human breast carcinoma tissue.

Polβ modulates the expression of type I interferon via STING pathway

JournalBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ApplicationWB,IHC

IF3.322

SpeciesHuman,Mouse

PMID35834922