Product Name :APP/β-Amyloid (E737) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200
Background :Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the β-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer’s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid β/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer’s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :APP/β-Amyloid (E737) polyclonal antibody detects endogenous levels of several isoforms of both mature and immature β-amyloid A4 precursor protein, including APP639, APP677, APP695, APP696, APP714, APP733, APP751 and APP752.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Neuronal and Glial Cell Marker Atlas,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,
Alternative Name :Amyloid beta A4 protein; ABPP; APPI; Short name=APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; Short name=CVAP; PreA4; Protease nexin-II; Short name=PN-II; N-APP; Soluble APP-alpha; Short name=S-APP-alpha; Soluble APP-beta; Short name=S-APP-beta; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; P3(42); P3(40); Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; Short name=AICD-59; Short name=AID(59); Gamma-CTF(59); Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; Short name=AICD-57; Short name=AID(57); Gamma-CTF(57); Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID(50); Gamma-CTF(50); APP; A4; AD; Amyloid-β; Amyloid β; Amyloidβ; β Amyloid; βAmyloid; Aβ
Immunogen :Synthetic peptide, corresponding to amino acids 701-750 of Human APP/β-Amyloid.
Modification :Unmodification
