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HLA-C monoclonal antibody

货号: MB23282

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB23282

Product Name :HLA-C monoclonal antibody

Swiss-Prot :P10321

Host :Mouse

Reactivity :Human, Mouse

Applications :WB,IHC

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000

Background :HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :40.6kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MHC; HLAC; HLC-C; D6S204; PSORS1; HLA-JY3

Immunogen :Purified recombinant fragment of human HLA-C (AA: 25-308) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using HLA-C mouse mAb against Mouse Liver (1) tissue lysate.

Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using HLA-C mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）