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SF3B2 polyclonal antibody

货号: BS8070

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS8070

Product Name :SF3B2 polyclonal antibody

Swiss-Prot :Q13435

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SF3B2 polyclonal antibody detects endogenous levels of SF3B2 protein.

BiowMW :~ 140 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SAP145; Splicing factor 3B subunit 2; Pre-mRNA-splicing factor SF3b 145 kDa subunit; SF3b145; SF3b150; Spliceosome-associated protein 145; SAP 145

Immunogen :Recombinant fusion protein of human SF3B2(NP_006833.2).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of SF3B2 expression in Hela (A), MCF7 (B), mouse testis (C) whole cell lysates.

Immunohistochemical analysis of SF3B2 staining in human lung cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of SF3B2 staining in A549 cells.