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ABCG2 polyclonal antibody

货号: BS78664

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS78664

Product Name :ABCG2 polyclonal antibody

Swiss-Prot :Q9UNQ0

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200|IF/ICC,1:50 - 1:200

Background :The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ABCG2 polyclonal antibody detects endogenous levels of ABCG2 protein.

BiowMW :~ 90, 65 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ABCP; BCRP; BCRP1; MXR; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; CD338

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ABCG2.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of ABCG2 expression in HEK293T (A), Hela (B), mouse kidney (C), rat lung (D), rat kidney (E), rat muscle (F), rat testis (G) whole cell lysates.

Immunohistochemical analysis of ABCG2 staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of ABCG2 staining in HepG2 cells.