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GFRA1 polyclonal antibody

货号: BS71951

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS71951

Product Name :GFRA1 polyclonal antibody

Swiss-Prot :P56159

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GFRA1 polyclonal antibody detects endogenous levels of GFRA1 protein.

BiowMW :55kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :GDNFRA; RETL1; TRNR1; GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1

Immunogen :Recombinant fusion protein of human GFRA1(NP_005255.1).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of GFRA1 expression in MCF7 (A), A549 (B), SW480 (C) whole cell lysates.

Immunohistochemical analysis of GFRA1 staining in human thyroid cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of GFRA1 staining in SW480 cells.