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Proprotein Convertase 9(PCSK9) polyclonal antibody

货号: BS71876

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS71876

Product Name :Proprotein Convertase 9(PCSK9) polyclonal antibody

Swiss-Prot :Q8NBP7

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC-P, IF/ICC, IP

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200|IP,1:50 - 1:200

Background :This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Proprotein Convertase 9(PCSK9) polyclonal antibody detects endogenous levels of Proprotein Convertase 9(PCSK9) protein.

BiowMW :80KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PCSK9;FH3;HCHOLA3;LDLCQ1;NARC-1;NARC1;PC9

Immunogen :A synthetic peptide of human Proprotein Convertase 9(PCSK9)(NP_777596.2).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of various lysates using Proprotein Convertase 9(PCSK9) pAb at 1:1000 dilution.

Immunohistochemistry analysis of paraffin-embedded Human pancreas tissue using Proprotein Convertase 9(PCSK9) pAb at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.

Immunofluorescence analysis of HepG2 cells using Proprotein Convertase 9(PCSK9) pAb at dilution of 1:200 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) at 1:500 dilution.

Immunoprecipitation of Proprotein Convertase 9(PCSK9) from 200 µg extracts of HeLa cells was performed using 0.5 µg of Proprotein Convertase 9(PCSK9) pAb.

Silibinin A decreases statin‑induced PCSK9 expression in human hepatoblastoma HepG2 cells

JournalMolecular Medicine Reports

ApplicationWB

IF2.1

SpeciesHuman

PMID31173243