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CCR2 polyclonal antibody

货号: BS70518

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS70518

Product Name :CCR2 polyclonal antibody

Swiss-Prot :P41597

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB,1:500 - 1:1000

Background :This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CCR2 polyclonal antibody detects endogenous levels of CCR2 protein.

BiowMW :42KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CCR2;CC-CKR-2;CCR-2;CCR2A;CCR2B;CD192;CKR2;CKR2A;CKR2B;CMKBR2;MCP-1-R;FLJ78302

Immunogen :A synthetic peptide of human CCR2(NP_001116513.2).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of extracts of RAW264.7 cells, using CCR2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 90s.

Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages

JournalCell Death & Disease

ApplicationWB

IF5.959

SpeciesHuman

PMID29500439
Enhanced antitumor immune response in melanoma-bearing mice via attenuated Salmonella carrying an IL-21-shRNA-CCR2 co-expression plasmid

JournalBIOCHEMICAL PHARMACOLOGY

ApplicationWB

IF5.6

SpeciesMouse

PMID40619018
MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response

JournalScientific Reports

ApplicationWB

IF3.9

SpeciesHuman

PMID40781135