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TAP2 polyclonal antibody

货号: BS6846

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6846

Product Name :TAP2 polyclonal antibody

Swiss-Prot :Q03519

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TAP2 polyclonal antibody detects endogenous levels of TAP2 protein.

BiowMW :75KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ABCB3; PSF2; RING11; Y1; Antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; Peptide supply factor 2; Peptide transporter PSF2; PSF-2; Peptide transporter TAP2; Peptide transporter involved in antigen processing 2; Really interesting new gene 11 protein

Immunogen :Recombinant fusion protein of human TAP2(NP_001276972.1).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of TAP2 expression in MCF7 (A), mouse spleen (B), mouse lung (C) whole cell lysates.

Immunohistochemical analysis of TAP2 staining in human colon cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of TAP2 staining in U2OS cells.