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STING Rabbit monoclonal antibody

货号: BS66245

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS66245

Product Name :STING Rabbit monoclonal antibody

Swiss-Prot :Q86WV6

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:500

Background :Stimulator of interferon genes (STING, TMEM173, MITA) is a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA . STING is a ubiquitously expressed protein found predominantly in the ER. The enzyme cGAMP synthase (cGAS) produces the second messenger cyclic-GMP-AMP (cGAMP) in response to cytoplasmic DNA . cGAMP binds and activates STING. In addition, detection of cytoplasmic DNA by nucleic acid sensors, including DDX41 or IFI16, results in STING activation . Following activation, STING translocates with TBK1 to perinuclear endosomes . The TBK1 kinase phosphorylates and activates interferon regulatory factors (IRFs) and NF-κB, which leads to the induction of type I interferon and other immune response genes .

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :STING Rabbit monoclonal antibody detects endogenous levels of STING protein.

BiowMW :~ 35 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ERIS; MITA; STING; TMEM173; Stimulator of interferon genes protein; hSTING; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173

Immunogen :Recombinant fusion protein of human STING.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of STING expression in MG63 (A), HUT78 (B), mouse kidney (C), mouse lung (D), rat kidney (E), rat lung (F) whole cell lysates.

Immunohistochemical analysis of STING staining in human colon cancer formalin fixed paraffin embedded tissue section.