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CYP17A1 polyclonal antibody

货号: BS6579

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6579

Product Name :CYP17A1 polyclonal antibody

Swiss-Prot :P05093

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF/ICC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:100 IF/ICC: 1:50~1:200

Background :CYP17A (17α-hydroxylase/17,20-lyase) is important for the conversion of pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione. In this process, it catalyzes both the 17α-hydroxylation and the 17,20-lyase reaction.CYP17A1 is crucial during sexual development, both during fetal development and during puberty, and is intracellularly regulated by cAMP levels. Defects in the CYP17A1 gene, which encodes for the protein, may cause adrenal hyperplasia type V (AH-V) which is characterized by hypokalemia and hypertension.Male patients affected by AH-V do not undergo normal sexual differentiation and develop female external genitalia and do not undergo pubertal develoment.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CYP17A1 polyclonal antibody detects endogenous levels of CYP17A1 protein.

BiowMW :~ 55 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CYP17; S17AH; Steroid 17-alpha-hydroxylase/17,20 lyase; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CYP17A1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of CYP17A1 expression in PC3 (A), U87MG (B), A2780 (C), PC12 (D), AML12 (E) whole cell lysates.

Immunohistochemical analysis of CYP17A1 staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of CYP17A1 staining in NIH3T3 cells.