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IRF-4 polyclonal antibody

货号: BS6104

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6104

Product Name :IRF-4 polyclonal antibody

Swiss-Prot :Q15306

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF/ICC

Application_all :WB: 1:500~1:1000 IHC: 1:100~1:200 IF/ICC: 1:100~1:500

Background :Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IRF4 polyclonal antibody detects endogenous levels of IRF4 protein.

BiowMW :~ 47 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MUM1; Interferon regulatory factor 4; IRF-4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IRF4.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of IRF4 expression in Hela (A), mouse lung (B), rat lung (C), rat spleen (D) whole cell lysates.

Immunohistochemical analysis of IRF4 staining in human tonsil formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of IRF4 staining in A549 cells.

Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

JournalBiochemical Pharmacology

ApplicationICC,WB

IF4.825

SpeciesMouse

PMID29753749