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TRAF2 polyclonal antibody

货号: BS6065

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6065

Product Name :TRAF2 polyclonal antibody

Swiss-Prot :Q12933

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IP

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:200|IP,1:10 - 1:50

Background :The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TRAF2 polyclonal Antibody detects endogenous levels of TRAF2 protein.

BiowMW :54kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TRAP3; TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3

Immunogen :Recombinant fusion protein of human TRAF2(NP_066961.2).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of TRAF2 expression in HeLa (A), PC12 (B), Romas (C), Jurkat (D), NIH3T3 (E) whole cell lysates.

Immunohistochemical analysis of TRAF2 staining in human colon cancer formalin fixed paraffin embedded tissue section.