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RBBP6 polyclonal antibody

货号: BS60233

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS60233

Product Name :RBBP6 polyclonal antibody

Swiss-Prot :Q7Z6E9

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB 1:500 - 1:1000 IHC 1:50 - 1:100

Background :Rb protein and p53 are both cell cycle checkpoint components. Evidence suggests that p53 plays a role in regulating the phosphorylation of Rb by inducing p21 transcription, thus preventing Rb phosphorylation at the G1 to S transition. Protein-protein interactions seem to be central in p53 cellular activities, as previously demonstrated with MDM2 and SV40 large T antigen. Two novel proteins have been identified by their abilities to bind to p53 and/ or Rb. Human RBQ-1 (also designated RBBP6) has been cloned as a novel protein that binds to the retinoblastoma (Rb) gene product. A related mouse protein, P2P-R, also designated PACT (for p53 associated cellular protein-testis derived), has been shown to bind to both Rb and p53. Recombinant P2P-R binds to wildtype p53 but not to mutant p53, and it can interfere with p53 specific DNA binding. RBQ-1 may be a truncated human form of the P2P-R protein.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :RBBP6 polyclonal antibody detects endogenous levels of RBBP6 protein.

BiowMW :~ 106 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :P2PR; PACT; RBQ1; E3 ubiquitin-protein ligase RBBP6; Proliferation potential-related protein; Protein P2P-R; Retinoblastoma-binding Q protein 1; RBQ-1; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human RBBP6.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of RBBP6 expression in HEK293T (A), HepG2 (B), Jurkat (C), mouse muscle (D), mouse kidney (E), rat muscle (F), rat kidney (G) whole cell lysates.

Immunohistochemical analysis of RBBP6 staining in human liver cancer formalin fixed paraffin embedded tissue section.