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MMP9 (W680) polyclonal antibody

货号: BS1241

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1241

Product Name :MMP9 (W680) polyclonal antibody

Swiss-Prot :P14780

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF/ICC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF/ICC: 1:50~1:200

Background :The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or taphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92-kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MMP9 (W680) polyclonal antibody detects endogenous levels of MMP9 protein.

BiowMW :~ 84 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB; MMP9; CLG4B

Immunogen :Recombinant protein corresponding to human MMP9.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of MMP9 expression in K562 (A), Raji (B), mouse brain (C), rat kidney (D) whole cell lysates.

Immunohistochemical analysis of MMP9 staining in mouse spleen formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of MMP9 staining in L929 cells.

Ubiquitin-specific peptidase 22 inhibits colon cancer cell invasion by suppressing the signal transducer and activator of transcription 3/matrix metalloproteinase 9 pathway

JournalMolecular Medicine Reports

ApplicationIHC

IF1.851

SpeciesHuman

PMID25902005
Targeted knockout of TNF‑α by injection of lentivirus‑mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats

JournalMolecular Medicine Reports

ApplicationWB

IF1.851

SpeciesRat

PMID26130073
Emodin inhibits migration and invasion of MHCC‑97H human hepatocellular carcinoma cells

JournalExperimental and Therapeutic Medicine

ApplicationWB

IF1.785

SpeciesHuman

PMID27882165
Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling

JournalOncotarget

ApplicationWB

IF0

SpeciesHuman

PMID26919254
Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway

JournalGenes & Diseases

ApplicationIHC,WB

IF4.803

SpeciesHuman

PMID33997170