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MMP-13 (L22) polyclonal antibody

货号: BS1231

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1231

Product Name :MMP-13 (L22) polyclonal antibody

Swiss-Prot :P45452

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The matrix metalloproteinases (MMP) are a family ofpeptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibroPVRL1, laminin and proteoglycan. Transcriptionof MMP genes is differentially activated by phorbol ester,lipopolysaccharide (LPS) or staphylococcal enterotoxin B(SEB). MMP catalysis requires both calcium and zinc.MMP-13 (also designated collagenase-3) is produced bybreast carcinomas and degrades collagen types I, II andIII. MMP-13 has wide substrate specificity, and its physiologic expression is limited to situations in which rapidand effective remodeling of collagenous ECM takesplace, such as fetal bone development and adult bone remodeling

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MMP-13 (L22) polyclonal antibody detects endogenouslevels of ~55 kDa latent or the ~40 kDa active forms ofMMP-13 protein.

BiowMW :~ 55, 40 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Collagenase 3; Matrix metalloproteinase-13 (MMP-13); MMP13

Immunogen :Synthetic peptide, corresponding to Human MMP-13.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of MMP-13 (L22) pAb at 1:500 dilution Lane1:K562 whole cell lysate(40ug) Lane2:MCF-7 whole cell lysate(40ug) Lane3:H1792 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of MMP-13 (L22) pAb in paraffin-embedded human breast carcinoma tissue

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