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EGFRvIII (2C10) monoclonal antibody（KU）

货号: MB8018

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB8018

Product Name :EGFRvIII (2C10) monoclonal antibody（KU）

Swiss-Prot :P00533

Host :Mouse

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :EGFR variant III (EGFRvIII) is a truncated, constitutively active mutant form of EGFR that results from an in-frame deletion of exons 2-7. EGFRvIII is expressed in various cancers, most notably glioblastoma, where it is expressed at a frequency of 25-30%. Although complicated by the fact that it is often co-expressed with amplified EGFR, EGFRvIII is a potential therapeutic target.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :EGFR vlII mAb detects endogenous levels of EGFR vlII protein.

BiowMW :~ 170 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ErbB HER Signaling,

Alternative Name :EGFR vIII; EGFR class lII variant; EGF Receptor vIII; EGFR variant III

Immunogen :A synthetic peptide corresponding to residues in Human EGFRvIII Peptide (LEEKKGNYVVTDHC).

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of EGFR vlII mAb at 1:1000 dilution Lane1:A549 whole cell lysate(40ug) Lane2:SGC7901 whole cell lysate(40ug) Lane3:NIH-3T3 whole cell lysate(40ug) Lane4:C6 whole cell lysate(40ug)