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Cytokeratin 18 monoclonal antibody

货号: MB0146

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB0146

Product Name :Cytokeratin 18 monoclonal antibody

Swiss-Prot :P05783

Host :Mouse

Reactivity :Human,Monkey

Applications :WB ICC

Application_all :WB: 1:500~2000 ICC: 1:200~1000

Background :Cytokeratin 18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of Cytokeratin 18 and does not cross-react with related proteins

BiowMW :Predicted band size:46KDa Observed band size:46KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Contribution of Soluble Factors to EMT,

Alternative Name :Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; Short name=CK-18; Keratin-18; Short name=K18; KRT18; CYK18; PIG46; KRT 18; CK 18; CK18; Keratin 18; Keratin18; CK-18

Immunogen :Recombinant full length Human Cytokeratin 18.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of krt18 antibody in Hela, COS7 and 293T cell lysates using krt18 antibody (1:2000 diluted) .