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GRK 2 / ADRBK1 monoclonal antibody

货号: MB0139

价格：￥ ——

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0139

Product Name :GRK 2 / ADRBK1 monoclonal antibody

Swiss-Prot :P25098

Host :Mouse

Reactivity :Human,Mouse

Applications :WB

Application_all :WB: 1:1000

Background :Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of β-adrenergic receptor kinase, GRK 2 (βARK, βARK1) and GRK 3 (βARK2); IT-11 (GRK 4); GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of ADRBK1 and does not cross-react with related proteins

BiowMW :Predicted band size:80KDa Observed band size:80KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :G Protein-coupled Receptors Signaling to MAPK Erk,

Alternative Name :Beta-adrenergic receptor kinase 1; Beta-ARK-1; β-ARK-1; ARK-β1; G-protein coupled receptor kinase 2; ADRBK1; BARK; BARK1; GRK2; ARK β1; ARKβ1; β-ARK1

Immunogen :Recombinant full length Human GRK 2 / ADRBK1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of ADRBK1 in U937, Raw264.7 & Ramos cell lysate (1:1000 diluted)