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GATA-6 monoclonal antibody

货号: MB0137

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB0137

Product Name :GATA-6 monoclonal antibody

Swiss-Prot :Q92908

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB: 1:200~1000

Background :Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T-lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4, expression.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of GATA-6 and does not cross-react with related proteins

BiowMW :Predicted band size:45KDa Observed band size:60KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ESC Pluripotency and Differentiation Signaling Pathway,

Alternative Name :Gata binding factor 6; Gata binding protein 6; GATA-binding factor 6; Gata6; Transcription factor Gata 6; Transcription factor GATA-6;

Immunogen :Recombinant full length Human GATA-6.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of GATA6 in HelaNE, Hela&293 cell lysates and using GATA6 antibody (1:200 diluted) .

Hypoxia-induced miR-181b enhances angiogenesis of retinoblastoma cells by targeting PDCD10 and GATA6

JournalOncology Reports

ApplicationWB

IF3.906

SpeciesHuman

PMID25872572