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DDB1 monoclonal antibody

货号: MB0133

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0133

Product Name :DDB1 monoclonal antibody

Swiss-Prot :Q16531

Host :Mouse

Reactivity :Human,Mouse,Rat,Monkey

Applications :WB

Application_all :WB,1:500 - 1:2000

Background :The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit.This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage.Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However,it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit.In addition,Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q,but no sequence alternations of this gene are demonstrated in Best disease patients.The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of DDB1 and does not cross-react with related proteins

BiowMW :~ 127 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1

Immunogen :Recombinant full length Human DDB1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of DDB1 in Hela, MCF-7, COS7, C6 and 3T3 lysates using DDB1 antibody.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）