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FKHR / FoxO1 (C-terminus) monoclonal antibody

货号: MB0093

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB0093

Product Name :FKHR / FoxO1 (C-terminus) monoclonal antibody

Swiss-Prot :Q12778

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB: 1:1000

Background :FOXO1A (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein which is a member of a subfamily of the forkhead homeotic gene family of transcription factors. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Chromosomal aberrations involving FOXO1A are a cause of rhabdomyosarcoma 2 (RMS2); also known as alveolar rhabdomyosarcoma.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of FOXO1 and does not cross-react with related proteins

BiowMW :Predicted band size:70KDa Observed band size:70KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :PI3K AKT signaling,Insulin &Glucose Signaling,

Alternative Name :Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; FOXO1; FKHR; FOXO1A

Immunogen :Synthetic peptide, corresponding to the C-terminus of Human FKHR.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of FOXO1 (C-terminus) antibody in A431&Hela cell lysates using FOXO1 (C-terminus) antibody (1:1000 diluted) .

Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging

JournalReproductive Biology and Endocrinology

ApplicationWB

IF4.4

SpeciesHuman

PMID37907924