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Ikaros (C-terminus) monoclonal antibody

货号: MB0092

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB0092

Product Name :Ikaros (C-terminus) monoclonal antibody

Swiss-Prot :Q13422

Host :Mouse

Reactivity :Human

Applications :WB IP

Application_all :WB: 1:1000 IP: 1:50~1:200

Background :Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs).

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of Ikaros and does not cross-react with related proteins

BiowMW :Predicted band size:58KDa Observed band size:58KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,B cell receptor signaling,

Alternative Name :DNA-binding protein Ikaros; Ikaros family zinc finger protein 1; Lymphoid transcription factor LyF-1; IKZF1; IK1; IKAROS; LYF1; ZNFN1A1

Immunogen :Synthetic peptide, corresponding to the C-terminus of Human Ikaros.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Ikaros (C-terminus) antibody in Ramos&Jurkat cell lysates using Ikaros (C-terminus) antibody (1:1000 diluted) .

The interacting domains in cereblon differentially modulate the immunomodulatory drug-mediated ubiquitination and degradation of its binding partners

JournalBiochemical And Biophysical Research Communications

ApplicationWB

IF2.705

SpeciesHuman

PMID30458989
Lys-63-specific deubiquitinase BRCC36 enhances the sensitivity of multiple myeloma cells to lenalidomide by inhibiting lysosomal degradation of cereblon

JournalCELLULAR AND MOLECULAR LIFE SCIENCES

ApplicationWB

IF6.2

SpeciesMouse,Human

PMID39136771