产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

DBC1 (3G4) monoclonal antibody

货号: MB0057

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0057

Product Name :DBC1 (3G4) monoclonal antibody

Swiss-Prot :Q8N163

Host :Mouse

Reactivity :Human,Mouse,Rat,Monkey

Applications :WB ICC IP

Application_all :WB: 1:500~1000 ICC: 1:50~200

Background :Core component of the DBIRD complex,a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing:the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions.Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis.Inhibits SUV39H1 methyltransferase activity.As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of DBC1 and does not cross-react with related proteins

BiowMW :Predicted band size:103KDa Observed band size:120KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DBC1; DBC-1; NET35; p30DBC; p30 DBC; DBC.1; DBIRD complex subunit; KIAA1967

Immunogen :Synthetic peptide, corresponding to the N-terminus of Human KIAA1967.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of DBC1 in HeLa,A549,Jurkat,C6,3T3 and COS7 cell lysates using DBC1 mouse mAb (1:500 diluted).

Immunocytochemistry of HeLa cells using anti-DBC1 mouse mAb diluted 1:200.

Immunoprecipitation analysis of Hela cell lysates using DBC1 mouse mAb.

免疫沉淀（IP）