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HDAC3 monoclonal antibody

货号: MB0035

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :MB0035

Product Name :HDAC3 monoclonal antibody

Swiss-Prot :O15379

Host :Mouse

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:1000

Background :Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of HDAC3 and does not cross-react with related proteins

BiowMW :Predicted band size:49KDa Observed band size:49KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Notch Signaling,Nuclear Receptor Signaling,Cell Cycle Control G1 S Checkpoint,Epigenetic Writers and Erasers of Histone H3,Epigenetic Writers and Erasers of Histones H2A H2B and H4,

Alternative Name :Histone deacetylase 3; HD3; RPD3-2; SMAP45; HDAC3

Immunogen :Recombinant full length Human HDAC3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of HDAC3 in THP-1, LNCAP, MCF7, PC12, 293, Jurkat, 3T3&Hela cell lysates using HDAC3 antibody (1:1000 diluted) .

The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition

JournalJournal of Translational Medicine

ApplicationWB

IF4.098

SpeciesHuman

PMID26856330