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AKR1B1 monoclonal antibody

货号: MB0032

价格：￥ ——

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0032

Product Name :AKR1B1 monoclonal antibody

Swiss-Prot :P15121

Host :Mouse

Reactivity :Human

Applications :WB ICC

Application_all :WB: 1:1000 ICC: 1:50~200

Background :Aldose reductase (also designated AKR1B1, ALDR1, ALR2 or AR) is member of the monomeric NADPH-dependent aldoketoreductase family. Aldose reductase, which has a molecular mass of 36 kDa, catalyzes the reduction of various aldehydes and has been implicated in the development of diabetic complications by catalyzing the reduction of the aldehyde form of glucose, to the corresponding sugar alcohol, sorbitol. This pathway plays a minor role in glucose metabolism in most tissues, however in diabetic hyperglycemia, cells undergoing insulin-independent uptake of glucose accumulate significant quantities of sorbitol. The resulting hyperosmotic stress to cells may be a cause of diabetic complications such as neuropathy, retinopathy, and cataracts. Aldose reductase is very similar to human aldehyde reductase, bovine prostaglandin F synthase and to the European common frog protein, rho-crystallin.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of AKR1B1 and does not cross-react with related proteins.

BiowMW :Predicted band size:36KDa Observed band size:36KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Aldose reductase; ldehyde reductase; Aldo-keto reductase family 1 member B1; AKR1B1; ALDR1

Immunogen :Recombinant full length Human AKR1B1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of AKR1B1 in HT1080, MCF7, A431&Hela cell lysates using AKR1B1 antibody (1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）