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CYP4F2 (M66) polyclonal antibody

货号: BS9135

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS9135

Product Name :CYP4F2 (M66) polyclonal antibody

Swiss-Prot :P78329

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :CYP4F isoforms are involved in the oxidation of important cellular mediators, such as leukotriene B4 (LTB4) and prostaglandins. CYP4F2 catalyzes ω-hydroxylation of LTB4 to a less potent proinflammatory eicosanoid, 20-OH-LTB4, as well as arachidonic acid. CYP4F2 is expressed in liver and kidney. Its expression is repressed by peroxisomal proliferators and induced by retinoic acid. X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA). CYP4F2 participates in the ω-hydroxylation of VLCFAs, which may provide an alternative mode of treatment for X-ALD patients.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CYP4F2 (M66) polyclonal antibody detects endogenous levels of CYP4F2 protein.

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cyp4f14; CYPIVF1; Cytochrome P450 LTB omega; Cytochrome P450; family 4; subfamily F; polypeptide 2; EC 1.14.14.1; Leukotriene B(4) 20 monooxygenase; Leukotriene B(4) omega hydroxylase; MGC126966; MGC93476; P450 A3;

Immunogen :Synthetic peptide, corresponding to amino acids 36-90 of Human CYP4F2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CYP4F2 polyclonal antibody at 1:1000 dilution Lane1:HEPG2 whole cell lysate(55ug) Lane2:LO2 whole cell lysate(38ug) Lane3:The liver tissue lysate of Rat(41ug) Lane4:The liver tissue lysate of Mouse(38ug)