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gp91-phox (I502) polyclonal antibody

货号: BS9035

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS9035

Product Name :gp91-phox (I502) polyclonal antibody

Swiss-Prot :P04839

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase complex expresses in phagocytes, neuroepithelial bodies, vascular smooth muscle cells, and endothelial cells. It includes a membranebound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet possess distinct expression patterns. gp91-phox expresses in eosinophils, neutrophils, monocytes, and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, with low expression in the uterus and prostate.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :gp91-phox (I502) polyclonal antibody detects endogenous levels of gp91-phox protein.

BiowMW :~ 91 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cytochrome b-245 heavy chain; CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein; gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1; gp91-phox; p22 phagocyte B-cytochrome; CYBB; NOX2

Immunogen :Synthetic peptide, corresponding to amino acids 471-510 of Human gp91-phox.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of gp91-phox pAb at 1:5000 dilution Lane1:EC9706 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:PC3 whole cell lysate(40ug)

Oxidative Burst of Circulating Neutrophils Following Traumatic Brain Injury in Human

JournalPLoS One

ApplicationWB,IHC

IF2.74

SpeciesHuman

PMID23894384
Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage and oxidative stress in a rat model of Parkinson's disease

JournalPharmacology Biochemistry And Behavior

ApplicationIHC,WB

IF2.519

SpeciesRat

PMID26394281