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CD206 polyclonal antibody

货号: BS90224

价格：￥ ——

货期：现货（1-2个工作日）

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No. :BS90224

Product Name :CD206 polyclonal antibody

Swiss-Prot :P22897(Human)

Host :Rabbit

Reactivity :Rat,Mouse

Applications :WB

Application_all :WB,1:100 - 1:500

Background :CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity :CD206 polyclonal antibody detects endogenous levels of CD206 protein.

BiowMW :~ 200 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor-Infiltrating Immune Cell Marker Guide,

Alternative Name :MRC1; CD206; CLEC13D; CLEC13DL; MMR; MRC1L1; bA541I19.1; hMR

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 610-860 of human Mannose Receptor/CD206 (NP_002429.1).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of HUVEC, using CD206 antibody (A8301) at 1:500 dilution.

Immunofluorescence analysis of Raw264.7 cells using TLR2 pAb at dilution of 1:200 (40x lens).

Mild photothermal effect of titania nanotubes array as a promising solution for peri-implantitis

JournalMATERIALS & DESIGN

ApplicationIF

IF7.991

SpeciesMouse,Rat

PMID
Mechanical Force Induced Self-Assembly of Chinese Herbal Hydrogel with Synergistic Effects of Antibacterial Activity and Immune Regulation for Wound Healing

JournalSmall

ApplicationIF

IF13.281

SpeciesMouse

PMID35491505