Product Name :Hox-B4 (A135) polyclonal antibody
Application_all :IHC: 1:50~1:200
Background :The homeobox genes encode a family of transcription factors that regulate development and postnatal tissue homeostasis. Encoded by the HOXB4 gene, the nuclear phosphoprotein HoxB4 plays a key role in regulating the balance between hematopoietic stem cell renewal and differentiation. Hematopoietic expression of HoxB4 is regulated by the binding of USF-1 and USF-2, the binding of which may be favored by cytokines promoting stem cell self-renewal versus differentiation. HoxB4 is dependent on AP-1 expression to induce changes in cellular proliferation and differentiation, which increases the levels of cyclin D1, thereby linking HoxB4 with key elements of the cell cycle machinery. HoxB4 also participates in the downregulation of c-Myc expression. It is expressed in developing hair follicles as well as in K-562 and HL-60 cells.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :HoxB4 (A135) polyclonal antibody detects endogenous levels of IHoxB4 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Homeobox protein Hox-B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F; HOX2F; HOXB4
Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human Hox-B4.
Modification :Unmodification
