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ALKBH1 polyclonal antibody

货号: BS7984

价格：￥ ——

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS7984

Product Name :ALKBH1 polyclonal antibody

Swiss-Prot :Q13686

Host :Rabbit

Reactivity :Human

Applications :WB IP

Application_all :WB 1:500 - 1:2000 IP 1:50 - 1:200

Background :ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ALKBH1 polyclonal antibody detects endogenous levels of ALKBH1 protein.

BiowMW :~ 43 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ABH; ABH1; alkB; AlkB, alkylation repair homolog 1 (E. coli); ALKB1_HUMAN; ALKBH; ALKBH1; Alkylated DNA repair protein alkB homolog 1; Alkylation repair homolog 1; Alkylation repair, alkB homolog; Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA lyase ABH1; DNA oxidative demethylase ALKBH1; hABH;

Immunogen :Recombinant full length Human ALKBH1.

Conjugate :Unconjugated

Modification :Unmodification

WesternBlot (WB) analysis of ALKBH1 polyclonal antibody