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WRNIP1 polyclonal antibody

货号: BS79194

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS79194

Product Name :WRNIP1 polyclonal antibody

Swiss-Prot :Q96S55

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB,1:500 - 1:2000

Background :Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :WRNIP1 polyclonal antibody detects endogenous levels of WRNIP1 protein.

BiowMW :72kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :WHIP; ATPase WRNIP1; Werner helicase-interacting protein 1

Immunogen :Recombinant fusion protein of human WRNIP1(NP_569079.1).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of WRNIP1 expression in HeLa (A) whole cell lysates.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）