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DIAPH1 polyclonal antibody

货号: BS7851

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS7851

Product Name :DIAPH1 polyclonal antibody

Swiss-Prot :O60610

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IF

Application_all :WB 1:500 - 1:2000 IF 1:50 - 1:100

Background :Dia 1 (also designated p140mDia) and Dia 2 (also designated p134mDia 2), mammalian homologs of Drosophila Diaphanous, belong to a family of formin-homology (FH) proteins, which are characterized by having tandemly aligned FH1 and FH2 domains in their carboxy terminal regions. The amino terminus of inactivated Dia 1 binds to the FH1 and FH2 domains, and is activated when GTP-bound Rho disrupts the intramolecular interaction of Dia 1 and converts it to an open conformation. Once activated, Dia 1 co-localizes with profilin and RhoA in dynamic plasma-membrane structures, and induces the formation of stress fibers in conjunction with the ROCK mediated signaling pathway. However, Dia 1 and ROCK activities antagonize each other in order to determine the thickness and density of the stress fibers formed. Dia 1 has also been implicated as the gene responsible for non-syndromic deafness.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :DIAPH1 polyclonal antibody detects endogenous levels of DIAPH1 protein.

BiowMW :~ 178kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Adherens Junction signaling,Death Receptor Signaling,

Alternative Name :DIAPH1; deafness, autosomal dominant 1; DFNA1; DIA1; DIAP1; DIAP1_HUMAN; DIAPH1; Diaphanous homolog 1 (Drosophila); diaphanous homolog 1; Diaphanous related formin 1; Diaphanous-related formin-1; DRF1; FLJ25265; hDIA1; LFHL1; low frequency hearing loss 1; p140DIA; Protein diaphanous homolog 1;

Immunogen :Recombinant full length Human DIAPH1.

Conjugate :Unconjugated

Modification :Unmodification

WesternBlot (WB) analysis of DIAPH1 polyclonal antibody