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ADAMTS5 polyclonal antibody

货号: BS74041

价格：￥ ——

货期：现货（1-2个工作日）

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No. :BS74041

Product Name :ADAMTS5 polyclonal antibody

Swiss-Prot :Q9UNA0

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ADAMTS5 polyclonal antibody detects endogenous levels of ADAMTS5 protein.

BiowMW :~ 73 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ADAMTS5; ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADAMTS-11; ADAMTS-5; ADAMTS11; ADMP-2; ADAM-TS11

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 731-930 of human ADAMTS5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ADAMTS5 polyclonal antibody at 1:1000 dilution. Lysates/proteins: 25ug per lane.

Ergosterol limits osteoarthritis development and progression through activation of Nrf2 signaling

JournalExperimental and Therapeutic Medicine

ApplicationWB

IF1.785

SpeciesMouse

PMID33488803